Bioanalytical Method

SR. NO. DRUG DETECTOR LLOQ ULOQ UNIT MATRIX USED
1 Acitretin LC-MS/MS 3.133 502.543 ng/ml Human Plasma
2 13 Cis Acitretin LC-MS/MS 2.376 393.390 ng/ml Human Plasma
All Trans Acitretin 2.494 408.109 ng/ml
3 13 Cis Acitretin LC-MS/MS 0.501 81.781 ng/ml Human Plasma
All Trans Acitretin 2.493 407.157 ng/ml
4 Acyclovir LC-MS/MS 10.433 2025.904 ng/ml Human Plasma
5 Amantadine LC-MS/MS 4.242 1005.002 ng/ml Human Plasma
6 Amitriptyline LC-MS/MS 0.990 96.130 ng/ml Human Plasma
Nortriptyline LC-MS/MS 0.984 95.539 ng/ml
7 Amlodipine LC-MS/MS 0.211 36.254 ng/ml Human Plasma
8 Amlodipine LC-MS/MS 0.199 20.089 ng/ml Human Plasma
9 Amlodipine LC-MS/MS 0.100 50.014 ng/ml Human Plasma
10 Amoxicillin HPLC UV 0.203 16.215 µg/ml Human Plasma
11 Amoxicillin HPLC Fluorescence 0.200 15.984 µg/ml Human Plasma
12 Amoxicillin LCMS/MS 0.201 20.015 µg/ml Human Plasma
13 Amoxicillin LCMS/MS 200.071 20001.130 ng/ml Human Plasma
Clavulanic Acid 50.019 5000.400 ng/ml
14 Anagrelide LC-MS/MS 0.498 32.226 µg/ml Human Plasma
15 Apovincaminic acid LC-MS/MS 1.144 305.100 µg/ml Human Plasma
16 Aripiprazole LC-MS/MS 0.102 99.996 ng/ml Human Plasma
17 Aspirin LC-MS/MS 20.408 1622.892 ng/ml Human Plasma(K2EDTA fortified by KF)
18 Atorvastatin LC-MS/MS 0.203 39.359 ng/ml Human Plasma
Orthohydroxy Atorvastatin LC-MS/MS 0.237 45.890 ng/ml Human Plasma
Parahydroxyatorvastatin LC-MS/MS 0.257 49.730 ng/ml Human Plasma
19 Azacitidine LCMS/MS 130.076 15007.807 ng/ml Rabbit Plasma
20 Azelaic Acid LC-MS/MS 535.135 54166.667 ng/ml Per Sq. cm Adhesive disk
21 Azithromycin HPLC ECD 24.350 1175.959 ng/ml Human Plasma
22 Azithromycin LC-MS/MS 4.760 610.578 ng/ml Human Plasma
23 Bendroflumethiazide HPLC Fluorescence 0.986 100.160 ng/ml Human Plasma
24 Bisoprolol LC-MS/MS 0.075 75.043 ng/ml Human Plasma
25 Bisoprolol LC-MS/MS 0.075 75.011 ng/ml Human Plasma
26 Buprenorphine LC-MS 55.826 7458.987 pg/ml Human Plasma
27 Norbuprenorphine LC-MS 60.057 7965.228 pg/ml Human Plasma
28 Carisoprodol LC-MS/MS 1.995 1999.977 ng/ml Human Plasma
29 Cefpodoxime HPLC UV 0.475 27.967 µg/ml Human Plasma
30 Cefprozil HPLC UV 0.478 28.144 µg/ml Human Plasma
31 Cefuroxime Sodium HPLC UV 0.226 26.636 µg/ml Human Plasma
32 Cephalexin HPLC UV 0.111 39.992 µg/ml Human Plasma
33 Celecoxib LC-MS/MS 20.049 1999.992 ng/ml Human Plasma
34 Cetirizine HPLC UV 26.477 1314.742 ng/ml Human Plasma
35 Cetirizine LC-MS/MS 2.752 1054.239 ng/ml Human Plasma
36 Cetirizine Hydrochloride LC-MS/MS 1.000 400.042 ng/ml Human Plasma
Pseudoephedrine Hydrochloride 2.499 1000.204 ng/ml Human Plasma
37 Cinacalcet LC-MS/MS 0.506 50.600 ng/ml Human Plasma
38 Ciprofloxacin HPLC UV 0.054 7.992 µg/ml Human Plasma
39 Clarithromycin HPLC ECD 24.293 2000.000 ng/ml Human Plasma
40 Clavulanic Acid HPLC UV 0.031 8.952 µg/ml Human Plasma
41 Clobazam HPLC UV 9.937 806.400 ng/ml Human Plasma
42 Clobazam LC-MS/MS 0.010 0.839 µg/ml Human Plasma
43 CLOBAZAM LC-MS/MS 0.501 499.995 ng/ml Human Plasma
44 CLONAZEPAM LC-MS/MS 0.201 50.000 ng/ml Human Plasma
45 Cyclosporine LC-MS/MS 2.036 700.066 ng/ml Human whole blood
46 D3-N,N Di Desmethyl Venlafaxine LC-MS/MS 2.016 200.738 ng/ml Human Plasma
47 D3-N,N Di Desmethyl Venlafaxine LC-MS/MS 2.006 499.437 ng/ml Human Urine
48 D3-N,O Di Desmethyl Venlafaxine LC-MS/MS 2.010 200.184 ng/ml Human Plasma
49 D3-N,O Di Desmethyl Venlafaxine LC-MS/MS 2.007 499.665 ng/ml Human Urine
50 D6-N Desmethyl Venlafaxine LC-MS/MS 2.025 201.678 ng/ml Human Plasma
51 D6-N Desmethyl Venlafaxine LC-MS/MS 2.006 499.393 ng/ml Human Urine
52 D6-O Desmethyl Venlafaxine LC-MS/MS 2.005 199.676 ng/ml Human Plasma
53 D6-O Desmethyl Venlafaxine LC-MS/MS 2.008 499.990 ng/ml Human Urine
54 D9- Venlafaxine LC-MS/MS 2.007 199.907 ng/ml Human Plasma
55 D9- Venlafaxine LC-MS/MS 2.008 499.846 ng/ml Human Urine
56 Venlafaxine HPLC Fluorescence 6.159 398.629 ng/ml Human Plasma
Desmethyl Venlafaxine HPLC Fluorescence 10.346 502.236 ng/ml Human Plasma
57 Venlafaxine LC-MS/MS 10.637 2065.425 ng/ml Human Plasma
58 Darunavir LC-MS/MS 4.972 5009.389 ng/ml Human Plasma
59 Desmethyl Venlafaxine LC-MS/MS 10.340 2007.808 ng/ml Human Plasma
60 Dextromethorphan HPLC Fluorescence 9.676 631.818 ng/ml Human Plasma
61 Dextromethorphan LC-MS/MS 0.540 60.455 ng/ml Human Plasma
62 Dexamethasone LC-MS/MS 0.425 100.675 ng/ml Human Plasma
63 Diltiazem HCL LC-MS/MS 0.479 639.886 ng/ml Human Plasma
64 Desacetyl Diltiazem LC-MS/MS 0.240 320.703 ng/ml Human Plasma
N-Desmethyl Diltiazem LC-MS/MS 0.240 320.129 ng/ml Human Plasma
65 Diltiazem HCL LC-MS/MS 5.010 748.982 ng/ml Human Plasma
Desacetyl Diltiazem LC-MS/MS 0.261 150.426 ng/ml Human Plasma
N-Desmethyl Diltiazem LC-MS/MS 0.527 304.068 ng/ml Human Plasma
66 Diphenhydramine LC-MS/MS 1.545 110.045 ng/ml Human Plasma
67 Diphenhydramine HCl HPLC Fluorescence 15.109 1076.254 ng/ml Human Plasma
68 Docetaxel LCMS/MS 3.871 1000.006 ng/ml Human Plasma
69 Dronedarone LCMS/MS 0.211 250.052 ng/ml Human Plasma
Desbutyl dronedarone LCMS/MS 0.211 249.963 ng/ml Human Plasma
70 Doxazosin LCMS/MS 0.201 16.008 ng/ml Human Plasma
71 Doxycycline HPLC UV 0.100 2.000 µg/ml Human Plasma
72 Dutasteride LC-MS/MS 73.760 5401.602 pg/ml Human Plasma
73 Erythromycine LC-MS/MS 49.978 5002.283 ng/ml Human Plasma
74 Estrone(unconjugated) LC-MS/MS 18.069 1609.978 pg/ml Bovine serum Albumin+Human plasma
Estradiol (unconjugated) LC-MS/MS 17.982 1602.236 pg/ml Bovine serum Albumin+Human plasma
75 Estrone sulfate (Total) LC-MS/MS 0.050 19.981 ng/ml Bovine serum Albumin+Human plasma
Estrone glucuronide LC-MS/MS 0.498 150.006 ng/ml Bovine serum Albumin+Human plasma
76 Estrdiol & Estrone GCMS 40.030 2588.160 pg/ml Bovine Serum Albumin
77 Ethacrynic Acid LCMS/MS 4.997 1000.283 ng/ml Human Plasma
78 Ethambutol LCMS/MS 0.122 12.188 µg/ml Human Plasma
79 Ethosuximide LCMS/MS 0.200 20.002 µg/ml Human Plasma
80 Etodolac R and S
R-(-) Etodolac LCMS/MS 0.150 15.006 µg/ml Human Plasma
S-(+) etodolac LCMS/MS 0.100 10.000 µg/ml Human Plasma
R-(-) Etodolac LCMS/MS 0.319 21.254 µg/ml Human Plasma
S-(+) etodolac LCMS/MS 0.075 5.001 µg/ml Human Plasma
R-(-) Etodolac LCMS/MS 0.437 49.999 µg/ml Human Plasma
S-(+) etodolac LCMS/MS 0.077 8.751 µg/ml Human Plasma
81 Exemestane LC-MS/MS 705.565 51642.081 pg/ml Human Plasma
82 Total Ezetimibe LC-MS/MS 0.567 250.599 ng/ml Human Plasma
83 Esomeprazole LC-MS/MS 4.996 4000.141 µg/ml Human Plasma
84 Fenofibric Acid HPLC UV 0.277 20.138 µg/ml Human Plasma
85 Fenofibric Acid LC-MS/MS 0.050 7.129 µg/ml Human Plasma
86 Fentanyl Citrate LC-MS/MS 20.007 2501.771 pg/ml Human Plasma
87 Fexofenadine LC-MS/MS 9.665 500.577 ng/ml Human Plasma
88 Flucloxacillin HPLC UV 0.344 2245.205 µg/ml Human Plasma
89 Fluconazole LC-MS/MS 50.334 5764.428 ng/ml Human Plasma
90 Fluindione HPLC UV 19.951 999.951 ng/ml Human Plasma
91 Fluvastatin LC-MS/MS 2.035 15019.681 ng/ml Human Plasma
92 Fulvestrant LC-MS/MS 0.085 16.040 ng/ml Human Plasma
93 Gabapentin LC-MS/MS 50.025 5000.986 ng/ml Human Plasma
94 Gabapentin LC-MS/MS 9.990 999.000 µg/ml Human Urine
95 Gatifloxacin HPLC UV 0.118 16.002 µg/ml Human Plasma
96 Gliclazide HPLC UV 0.205 11.784 µg/ml Human Plasma
97 Gliclazide LC-MS/MS 20.414 2019.99 ng/ml Human Plasma
98 Glipizide LC-MS/MS 5.086 1000.162 ng/ml Human Plasma
99 Glucosamine LC-MS/MS 49.787 2786.000 ng/ml Human Plasma
100 Granisetron HPLC Fluorescence 0.361 96.378 ng/ml Human Plasma
101 Guaifenesin LC-MS/MS 0.010 2.520 µg/ml Human Plasma
102 Hydrocortisone LC-MS/MS 5.003 500.009 ng/ml Human Plasma
103 Hydrocortisone LC-MS/MS 10.522 600.011 ng/ml Human Plasma
104 Hydrochlorothiazide LC-MS/MS 5.184 503.284 ng/ml Human Plasma
Hydrochlorothiazide LC-MS/MS 1.002 499.998 ng/ml Human Plasma
Hydrochlorothiazide LC-MS/MS 4.501 719.999 ng/ml Human Plasma
105 Hydroxyzine LCMS/MS 2.130 198.673 ng/ml Human Plasma
106 Ibuprofen LCMS/LC-MS 0.370 80.036 µg/ml Human Plasma
107 R-Ibuprofen LCMS/MS 0.184 92.253 µg/ml Human Plasma
S-Ibuprofen LCMS/MS 0.184 92.271 µg/ml Human Plasma
108 Indomethacin LC-MS/MS 20.016 2001.940 ng/ml Human Plasma
109 Isoniazide HPLC UV 0.272 20.000 µg/ml Human Plasma
110 Isosorbide-5-Mononitrate LC-MS/MS 50.077 5042.449 ng/ml Human Plasma
111 Isotretinoin HPLC UV 11.040 812.000 ng/ml Human Plasma
112 Itraconazole HPLC Fluorescence 2.094 119.711 ng/ml Human Plasma
113 Itraconazole LC-MSMS 1.021 252.075 ng/ml Human Plasma
hydroxy itraconazole LC-MSMS 1.021 252.059 ng/ml Human Plasma
114 Total Iron* ICP-OES 25.3 2010.00 µg/dL Human Serum
115 Transferrin Bound Iron* ICP-OES 9.1 1080.0 µg/dL Human Serum
116 Lansoprazole LC-MS/MS 5.356 2142.894 ng/ml Human Plasma
117 Levothyroxine LC-MS/MS 3.006 299.998 ng/ml Human Serum
118 Levomilnacipran LC-MS/MS 1.013 500.499 ng/ml Human Plasma
119 Meloxicam HPLC UV 51.303 4019.800 ng/ml Human Plasma
120 Meloxicam LC-MS/MS 0.010 15.000 µg/ml Human Plasma
121 Memantine Hydrochloride LC-MS/MS 0.249 200.428 ng/ml Human Plasma
122 Metaxalone LC-MS/MS 25.190 2521.313 ng/ml Human Plasma
123 Metformin HPLC UV 30.000 5000.000 ng/ml Human Plasma
124 Metformin LC-MS/MS 5.014 1601.075 ng/ml Human Plasma
125 Metoprolol HPLC Fluorescence 5.000 500.000 ng/ml Human Plasma
126 Metoprolol LC-MS/MS 0.504 126.024 ng/ml Human Plasma
127 Metoprolol LC-MS/MS 0.500 40.110 ng/ml Human Plasma
128 Metoprolol LC-MS/MS 0.533 264.294 ng/ml Human Plasma
129 Mesalamine LC-MS/MS 2.007 1599.953 ng/ml Human Plasma
130 Mesalamine LC-MS/MS 1.925 912.180 ng/ml Human Plasma
131 Methylphenidate LC-MS/MS 0.100 49.997 ng/ml Human Plasma
132 Methylprednisolone LC-MS/MS 0.501 26.206 ng/ml Human Plasma
133 Memantine HCl LC-MS/MS 0.502 200.733 ng/ml Human Plasma
Donepezil HCl LC-MS/MS 0.501 200.527 ng/ml Human Plasma
134 Mizolastine HPLC UV 21.746 1599.414 ng/ml Human Plasma
135 Montelukast LC-MS/MS 5.061 1019.962 ng/ml Human Plasma
136 Mosapride HPLC Fluorescence 5.000 100.000 ng/ml Human Plasma
137 Naproxen LC-MS/MS 0.101 50.204 µg/ml Human Plasma
138 Nebivolol LC-MS/MS 0.075 8.000 ng/ml Human Plasma
139 Nevirapine LC-MS/MS 55.115 5499.998 ng/ml Human Plasma
140 Nicotine LC-MS/MS 1.001 101.773 ng/ml Human Plasma
Cotinine LC-MS/MS 1.008 102.433 ng/ml Human Plasma
141 Nifedipine LC-MS/MS 0.500 200.376 ng/ml Human Plasma
142 Nefopam LC-MS/MS 0.500 100.016 ng/ml Human Plasma
143 Nimodipine LC-MS/MS 0.100 40.022 ng/ml Human Plasma
144 Nitrofurantoin LC-MS/MS 2.008 2004.183 ng/ml Human Plasma
145 Norethindrone LC-MS/MS 200.134 17133.696 pg/ml Human Plasma
146 Norfloxacin HPLC Fluorescence 4.990 800.097 ng/ml Human Plasma
147 Nortriptyline LC-MS/MS 0.202 20.001 ng/ml Human Plasma
148 Olanzapine LC-MS/MS 0.510 100.148 ng/ml Human Plasma
149 Olmesartan Acid LC-MS/MS 15.630 2500.084 ng/ml Human Plasma
150 Olmesartan LC-MS/MS 15.630 2500.084 ng/ml Human Plasma
Hydrochlorothiazide LC-MS/MS 4.501 719.999 ng/ml Human Plasma
151 Oxcarbazepine LC-MS/MS 10.250 5070.362 ng/ml Human Plasma
10-OH,10,11 Dihydro Carbamazepine LC-MS/MS 102.181 10109.049 ng/ml Human Plasma
10-OH,10,11 Dihydro Carbazepine LC-MS/MS 212.624 9902.819 ng/ml Human Plasma
152 Oxybutynin LC-MS/MS 75.834 7092.568 pg/ml Human Plasma
N- Desethyl Oxybutynin LC-MS/MS 75.101 7046.890 pg/ml Human Plasma
153 Oxybutynin LC-MS/MS 75.051 7400.849 pg/ml Human Plasma
N- Desethyl Oxybutynin LC-MS/MS 75.163 7411.923 pg/ml Human Plasma
154 Paracetamol LC-MS/MS 154.099 10062.000 ng/ml Human Plasma
155 Paracetamol LC-MS/MS 0.149 10.080 µg/ml Human Plasma
156 Paroxetine LC-MS/MS 0.317 30.783 ng/ml Human Plasma
157 Paliperidone LC-MS/MS 0.050 38.540 ng/ml Human Plasma
158 Paroxetine LC-MS/MS 0.050 16.710 ng/ml Human Plasma
159 Penciclovir LC-MS/MS 52.555 6626.181 ng/ml Human Plasma
160 piroxicam LC-MS/MS 0.060 6.009 µg/ml Human Plasma
161 Piperacillin HPLC UV 1.005 100.049 µg/ml Human Plasma
162 Pramipexole LC-MS/MS 19.015 4756.993 pg/ml Human Plasma
163 Pramipexole LC-MS/MS 18.913 4760.956 pg/ml Human Plasma
164 Pravastatin LC-MS/MS 0.500 500.695 ng/ml Human Plasma(K2EDTA fortified by KF)
165 Prochloroperazine LCMS/MS 15.378 1401.351 pg/ml Human Plasma
166 Progesterone LC-MS/MS 0.075 27.015 ng/ml Human Plasma
167 Progesterone LC-MS/MS 0.101 27.227 ng/ml Human Serum
168 Progesterone LC-MS/MS 0.075 27.015 ng/ml Human Plasma
169 Propranolol HPLC Fluorescence 4.915 641.812 ng/ml Human Plasma
170 Paroxetine LC-MS/MS 0.049 16.337 ng/ml Human Plasma
171 Pyrazinamide HPLC UV 0.400 40.004 µg/ml Human Plasma
172 Quetiapine LC-MS/MS 10.075 2008.936 ng/ml Human Plasma
173 Quinaprilat LC-MS/MS 25.288 2455.200 ng/ml Human Plasma
Quinpril LC-MS/MS 4.541 454.214 ng/ml Human Plasma
174 Ranitidine HPLC UV 0.025 1.801 µg/ml Human Plasma
175 Reboxetine HPLC UV 20 to 500.000 ng/ml Human Plasma
176 Resveratrol LC-MS/MS 5.761 2405.484 ng/ml Human Plasma
177 Retinoic acid HPLC UV 21.655 2424.000 ng/ml Human Plasma
178 Rosuvastatin LC-MS/MS 0.251 89.293 ng/ml Human Plasma
Ezetimibe (Free) LC-MS/MS 0.100 35.714 ng/ml Human Plasma
179 Rosuvastatin LC-MS/MS 0.750 100.091 ng/ml Human Plasma
180 Roxithromycin HPLC UV 0.500 200.000 µg/ml Human Plasma
181 Roxithromycin HPLC ECD 0.427 20.116 µg/ml Human Plasma
182 Rifaximin LC-MSMS 0.050 10.002 ng/ml Human Plasma
183 Sertraline HPLC UV 0.011 0.432 µg/ml Human Plasma
184 Sildenafil HPLC UV 6.603 480.337 ng/ml Human Plasma
185 Sumatriptan LCMS/MS 1.028 97.912 ng/ml Human Plasma
186 Tadalafil LCMS/MS 2.506 500.073 ng/ml Human Plasma
187 Terbinafine LC-MS/MS 15.917 1595.527 ng/ml Human Plasma
188 Tiagbine LC-MS/MS 0.513 203.705 ng/ml Human Plasma
189 Tianeptine LC-MS/MS 2.517 500.941 ng/ml Human Plasma
190 Topiramate LC-MS/MS 0.025 5.050 µg/ml Human Plasma
191 Torsemide LC-MS/MS 0.063 24.002 µg/ml Human Plasma
192 Torsemide LC-MS/MS 0.126 24.007 µg/ml Human Urine
193 Triamcinolone acetonide LC-MS/MS 1.047 599.976 ng/ml Human Plasma
194 Triamcinolone acetonide LC-MS/MS 50.285 5000.870 pg/ml Human Plasma
195 Trifluoperazine GCMS 4.845 316.361 ng/ml Human Plasma
196 Trimetazidine LC-MS/MS 1.195 119.519 ng/ml Human Plasma
197 Ursodiol LC-MS/MS 30.400 3040.000 ng/ml Human Plasma
Glycodeoxycholic Acid (GDCA) LC-MS/MS 30.415 3041.529 ng/ml Human Plasma
Sodium Tauroursodeoxycholate (TDCA) LC-MS/MS 30.396 3039.597 ng/ml Human Plasma
198 Valproic Acid LC-MS/MS 0.560 100.980 µg/ml Human Plasma
199 Valproic Acid LC-MS/MS 1.048 100.232 µg/ml Human Plasma
200 Valsartan LC-MS/MS 0.098 20.099 µg/ml Human Plasma
201 Vinpocetine LC-MS/MS 0.193 25.754 ng/ml Human Plasma
202 Warfarin HPLC Fluorescence 11.087 1115.814 ng/ml Human Plasma
203 Ziprasidone LC-MS/MS 0.669 199.999 ng/ml Human Plasma
204 Zolpidem HPLC Fluorescence 5.923 441.196 ng/ml Human Plasma
205 Zopiclone HPLC UV 1.052 102.169 ng/ml Human Plasma
1 Lamivudine, Under Validation
EFAVIRENZ
TENOFOVIR
2 Clonidine Under Development
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